On their first intake people cough, choke, wheeze, and make grimaces equivocal to that of people eating spoiled meat. Then the 'trip' or 'high' can go up into the lofty clouds just as easily as it sends one into the pits of despair. As well, any passing thought can become a long and sustained episode, and with time and commitment, this erratic mood can continue ad nauseam.
Of course, I remember that people don't really use drugs for the sake of using drugs, they use drugs to forget.
I wish I remembered more.